Minor-Obstructions for Apex-Pseudoforests

A graph is called a pseudoforest if none of its connected components contains more than one cycle. A graph is an apex-pseudoforest if it can become a pseudoforest by removing one of its vertices. We identify 33 graphs that form the minor-obstruction set of the class of apex-pseudoforests, i.e., the set of all minor-minimal graphs that are not apex-pseudoforests

Minor­Obstructions for Apex Pseudoforests

Ένα γράφημα ανήκει στην κλάση των ψευδοδασών αν κάθε συνεκτική συνιστώσα του περιέχει το πολύ έναν κύκλο. Ένα γράφημα είναι απόγειο­ψευδοδάσος αν μπορεί να μετατραπεί σε ψευδοδάσος με την αφαίρεση μίας κορυφής. Έχουμε εντοπίσει τα 33 γραφήματα τα οποία αποτελούν το σύνολο παρεμπόδισης για την κλάση γραφημάτων απόγεια­ψευδοδάση, δηλαδή τα ελαχιστικά γραφήματα ως προς την σχέση του ελάσσονος, τα οποία δεν είναι απόγεια­ψευδοδάση.A graph is called a pseudoforest if none of its connected components contains more than one cycle. A graph is an apex­pseudoforest if it can become a pseudoforest by removing one of its vertices. We identify 33 graphs that form the minor obstruction set of the class of apex­pseudoforests, i.e., the set of all minor­minimal graphs that are not apex­pseudoforests

Diet supplementation with fish‐derived extracts suppresses diabetes and modulates intestinal microbiome in a murine model of diet‐induced obesity

Metabolic syndrome-related diseases affect millions of people worldwide. It is well established that changes in nutritional habits and lifestyle can improve or prevent metabolic-related pathologies such as type-2 diabetes and obesity. Previous reports have shown that nutritional supplements have the capacity to limit glucose intolerance and suppress diabetes development. In this study, we investigated the effect of dietary supplementation with fish-derived extracts on obesity and type 2 diabetes and their impact on gut microbial composition. We showed that nutritional supplements containing Fish Complex (FC), Fish Complex combined with Cod Powder (FC + CP), or Cod Powder combined with Collagen (CP + C) improved glucose intolerance, independent of abdominal fat accumulation, in a mouse model of diet-induced obesity and type 2 diabetes. In addition, collagen-containing supplements distinctly modulate the gut microbiome in high-fat induced obesity in mice. Our results suggest that fish-derived supplements suppress diet-induced type 2 diabetes, which may be partly mediated through changes in the gut microbiome. Thus, fish-derived supplements and particularly the ones containing fish collagen have potential beneficial properties as dietary supplements in managing type 2 diabetes and metabolic syndrome via modulation of the gut microbiome.publishedVersio

Diet supplementation with fish‐derived extracts suppresses diabetes and modulates intestinal microbiome in a murine model of diet‐induced obesity

Metabolic syndrome-related diseases affect millions of people worldwide. It is well established that changes in nutritional habits and lifestyle can improve or prevent metabolic-related pathologies such as type-2 diabetes and obesity. Previous reports have shown that nutritional supplements have the capacity to limit glucose intolerance and suppress diabetes development. In this study, we investigated the effect of dietary supplementation with fish-derived extracts on obesity and type 2 diabetes and their impact on gut microbial composition. We showed that nutritional supplements containing Fish Complex (FC), Fish Complex combined with Cod Powder (FC + CP), or Cod Powder combined with Collagen (CP + C) improved glucose intolerance, independent of abdominal fat accumulation, in a mouse model of diet-induced obesity and type 2 diabetes. In addition, collagen-containing supplements distinctly modulate the gut microbiome in high-fat induced obesity in mice. Our results suggest that fish-derived supplements suppress diet-induced type 2 diabetes, which may be partly mediated through changes in the gut microbiome. Thus, fish-derived supplements and particularly the ones containing fish collagen have potential beneficial properties as dietary supplements in managing type 2 diabetes and metabolic syndrome via modulation of the gut microbiome.publishedVersio

Minor obstructions for apex-pseudoforests

International audienceA graph is called a pseudoforest if none of its connected components contains more than one cycle. A graph is an apex-pseudoforest if it can become a pseudoforest by removing one of its vertices. We identify 33 graphs that form the minor obstruction set of the class of apex-pseudoforests, i.e., the set of all minor-minimal graphs that are not apex-pseudoforests

Minor obstructions for apex-pseudoforests

A graph is called a pseudoforest if none of its connected components contains more than one cycle. A graph is an apex-pseudoforest if it can become a pseudoforest by removing one of its vertices. We identify 33 graphs that form the minor obstruction set of the class of apex-pseudoforests, i.e., the set of all minor-minimal graphs that are not apex-pseudoforests. (C) 2021 Elsevier B.V. All rights reserved

Fish Sidestream-Derived Protein Hydrolysates Suppress DSS-Induced Colitis by Modulating Intestinal Inflammation in Mice

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Fish-Derived Protein Hydrolysates Increase Insulin Sensitivity and Alter Intestinal Microbiome in High-Fat-Induced Obese Mice

Obesity and type 2 diabetes are characterized by low-grade systemic inflammation and glucose intolerance, which can be partially controlled with nutritional interventions. Protein-containing nutritional supplements possess health-promoting benefits. Herein, we examined the effect of dietary supplementation with protein hydrolysates derived from fish sidestreams on obesity and diabetes, utilizing a mouse model of High-Fat Diet-induced obesity and type 2 diabetes. We examined the effect of protein hydrolysates from salmon and mackerel backbone (HSB and HMB, respectively), salmon and mackerel heads (HSH and HMH, respectively), and fish collagen. The results showed that none of the dietary supplements affected weight gain, but HSH partially suppressed glucose intolerance, while HMB and HMH suppressed leptin increase in the adipose tissue. We further analyzed the gut microbiome, which contributes to the metabolic disease implicated in the development of type 2 diabetes, and found that supplementation with selected protein hydrolysates resulted in distinct changes in gut microbiome composition. The most prominent changes occurred when the diet was supplemented with fish collagen since it increased the abundance of beneficial bacteria and restricted the presence of harmful ones. Overall, the results suggest that protein hydrolysates derived from fish sidestreams can be utilized as dietary supplements with significant health benefits in the context of type 2 diabetes and diet-induced changes in the gut microbiome

Collagen-Containing Fish Sidestream-Derived Protein Hydrolysates Support Skin Repair via Chemokine Induction

Restoring homeostasis following tissue damage requires a dynamic and tightly orchestrated sequence of molecular and cellular events that ensure repair and healing. It is well established that nutrition directly affects skin homeostasis, while malnutrition causes impaired tissue healing. In this study, we utilized fish sidestream-derived protein hydrolysates including fish collagen as dietary supplements, and investigated their effect on the skin repair process using a murine model of cutaneous wound healing. We explored potential differences in wound closure and histological morphology between diet groups, and analyzed the expression and production of factors that participate in different stages of the repair process. Dietary supplementation with fish sidestream-derived collagen alone (Collagen), or in combination with a protein hydrolysate derived from salmon heads (HSH), resulted in accelerated healing. Chemical analysis of the tested extracts revealed that Collagen had the highest protein content and that HSH contained the great amount of zinc, known to support immune responses. Indeed, tissues from mice fed with collagen-containing supplements exhibited an increase in the expression levels of chemokines, important for the recruitment of immune cells into the damaged wound region. Moreover, expression of a potent angiogenic factor, vascular endothelial growth factor-A (VEGF-A), was elevated followed by enhanced collagen deposition. Our findings suggest that a 5%-supplemented diet with marine collagen-enriched supplements promotes tissue repair in the model of cutaneous wound healing, proposing a novel health-promoting use of fish sidestream